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Moreover, AMPK activation of insulin induced gene 1 (INSIG) inhibits the cleavage of SREBP1c and reduces lipogenic gene expression and lipid accumulation [114]

An emphasis on rigorous, large-scale trials, innovative delivery, and mechanistic clarity will help integrate curcumin more fully into evidence-based oral healthcare

Further studies are needed to clarify the exact mechanisms by which KD influences the development of PP

Metabolic rate (influenced by thyroid function, body composition, and physical activity) also modulates drug clearance, with higher metabolic rates potentially shortening half life and lower rates extending it