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Furthermore, GSH cannot cross cell membranes, but first needs to be broken down into its constituent amino acids and then re-synthesised inside the cell

Consistent with our observations in yeast, the difference in NADPH occupancy suggests a close match of the response ranges of both sensor variants with the physiological NADP redox state ( Figure S8 ), which may be estimated at about 0.3

Table 7

Disclosures: Jesse Pustjens: Nothing to Disclose, Laurens van Kleef: Nothing to Disclose, Harry Janssen: Gilead Sciences: and consultant, Gilead Sciences: Grant/Research Support, GlaxoSmithKline: Grant/Research Support, Janssen: Grant/Research Support, Roche: Grant/Research Support, Vir Biotechnology Inc.: Grant/Research Support, Aligos: Consultant, Gilead Sciences: Consultant, GlaxoSmithKline: Consultant, Grifols: Consultant, Roche: Consultant, Vir Biotechnology Inc: Consultant, Precision Biosciences: Consultant, Willem Pieter Brouwer: Nothing to Disclose 1121 INCREASING LIVER FIBROSIS IN MASLD IS ASSOCIATED WITH HIGHER RISK OF HIP FRACTURES IN MALES Elena Gibson 1 Meagan Gray 1 Fernando Bril 1 , 1 University of Alabama at Birmingham Background: Cirrhosis is associated with osteoporosis and increased risk of fractures