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IFNy not only promotes proteasomal cleavages that determine the C termini of antigenic peptides, but also can (independently of proteasomes) stimulate formation of their N termini by inducing LAP (leucine amino peptidase)

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That is, regardless of whether the biosimilar biological product meets the definition of a Part B rebatable drug or whether a rebate amount is owed for such biosimilar biological product for that applicable calendar quarter, CMS will apply the 75 percent reduction in the total rebate amount as set forth in 427.402(b)(1), even if there is no rebate amount owed to reduce

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