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For the dose of CB-839 10 M, on average, 89% (range 79.2-92.7%) of HG-3 cells and 75% (range, 63-85,8%) of MEC-1 cells remained viable after 72 hours of incubation ( Figure 3B )

Access this article Similar content being viewed by others Abbreviations AIF: apoptosis-inducing factor AMPK: serine/threonine AMP-activated protein kinase ARE: antioxidant responsive element ASK1: apoptosis signal-regulating kinase-1 BSO: buthionine sulfoximine ERK: extracellular signal-regulated kinase -GCL: -glutamylcysteine ligase GPx: glutathione peroxidase Grx: glutaredoxin GS: glutathione synthetase GSH/GSSG: glutathione reduced/oxidized GST: glutathione S-transferase -GT: -glutamyltransferase JNK: c-Jun N-terminal kinase LPO: lipid peroxidation MAPK: mitogen-activated protein kinase mGSH: mitochondrial glutathione nGSH: nuclear glutathione OGC: 2-oxyglutarate carrier PARP: poly(ADP-ribose)polymerase Prx: peroxiredoxin RNS: reactive nitrogen species ROS: reactive oxygen species Trx: thioredoxin TrxR: thioredoxin reductase References Nagy, P

Henssler J, Heinz A, Brandt L, Bschor T