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In T2D patients (n = 25, age 2565), consumption of 1 g L-citrulline twice a day for 4 weeks reduces the T2D-induced increase in arginase activity and increases plasma nitrites, effects corroborated by improvement of ACh-induced relaxation in ex vivo mouse aortic rings incubated (24-h) in low or high glucose-containing media and increases in NO production in ECs treated with high glucose (Shatanawi et al., 2020)

The ERO1-PDI axis is thought to be the main pathway for disulfide bond formation in ER (Wang et al., 2014)

Acknowledgements The study is supported by a Singapore EDB-IPP grant (grant number: RL2012035)

When it is compromised, skin becomes more vulnerable to bacteria, pollution, allergens, and UV damage