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The plasma clearance of parent BCNU decreases and the plasma half-life increases as doses escalate from standard-dose (150 to 200 mg/m2) to high-dose regimens (600 mg/m 2 ) (Table 14A-1)

When the heat index is above 100, even just the shortest period outside can cause harm especially considering that the vast majority of adults drink less than half of their recommended fluid intake throughout the day

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Compared with APP-treated saline, the elevation of reactive oxygen species (ROS) levels in serum was significantly smaller, implying that an antioxidant system existed in serum