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This Wnt-axis activity helps explain several otherwise disconnected observations why GHK-Cu promotes hair regrowth, why it extends fibroblast proliferative lifespan, and why it appears to reset certain senescence markers in aged skin cells

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We next used the transgenic strains to examine the tissue-specific expression of RIPS-1 and found specific transgene expression in the cytoplasm of the gut and hypodermal cells following treatment with 5 mM DTT (Fig