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We have included the druglike and ADME data of the potential candidates of Supplementary Table 9 in a separate supplementary Excel file ( Both the druglike and the ADME were predicted using the model of CMPNN (Communicative Message Passing Neural Network, 53

95 Tanaka-KagawaT.JinnoH.HasegawaT.MakinoY.SekoY.HanjokaN.AndoM

Intravenous (IV) Glutathione IV therapy delivers glutathione directly into the vein

This could be partly explained by the limited protection of Nrf2 against disease markers in backcross experiments between ALS mice and Nrf2-null mice, presumably as a result of compensatory mechanisms (Vargas et al