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Dysbiosis can affect the kynurenine pathway of tryptophan metabolism, leading to an imbalance in neuroactive metabolites that influence mood, cognition, and pain perception (He et al., 2023)

in an orthotopic brain-tumor model, intrathecal administration further increased tumor uptake to 18.10 0.87%ID/g, with a tumor-to-brain ratio of 14.23 at 24 hsignificantly higher than blockade and isotype-control groups (p 100 days, and complete remissions were achieved in subcutaneous models [69, 70]

The temperature and atmosphere mixture of 5% CO with compressed air was controlled by an Okolab Bold Line top stage incubator with an H301-K-Frame chamber (Okolab S.r.l., Italy)