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Naringenin supplementation for 1 month can reduce lipid peroxidation and decrease the expression of PKC, NF-B, cyclin D1(CCND1) and cyclin-dependent kinase 4 (CDK4), thereby inhibiting the proliferation of glioma cells in mouse models (366)

Furthermore, according to a randomized trial conducted in a population of patients with T2D receiving metformin for at least 4 years and experiencing diabetic neuropathy, administration of 1 mg oral methylcobalamin for 1 year was associated with a significant improvement in neurophysiological parameters and scores assessing neuropathic pain and quality of life [58]

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As a result, increasing emphasis has been placed on promoting and delineating nerve regeneration