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Chemical profiling of samples prior to evaluating their biological activity is clearly crucial, and it is important that the biological studies be informed by the results of the chemical analyses

10.2147/IJN.S213883 53 JelovacN.SikiricP.RucmanR.PetekM.MarovicA.PerovicD.et al (1999)

Twice-daily dosing is used in some early-phase research protocols to maintain more consistent receptor activation during the initial neuroplasticity induction period, but this approach increases total daily exposure and may elevate the risk of off-target effects