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Gut barrier damage and endotoxemia: mechanisms and effects Under hyperthermic conditions, superficial blood vessels dilate to dissipate heat, leading to reduced blood flow to visceral organs (especially the intestinal mucosa) in a murine heat stress model, which in turn causes damage and apoptosis of intestinal epithelial cells, increased intestinal epithelial permeability, and impaired intestinal mucosal barrier [17]

For a summary of the worker findings, see Table 1

Conversely, chronic iron accumulation can promote M2-like polarization, supporting an immunosuppressive environment [100]

McInnes L, Healy J, Saul N, Grossberger L