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In the canonical pathway of pyroptosis, intracellular pattern recognition receptors (PRRs) recognize PAMPs (Pathogen-Associated Molecular Patterns) or Damage-Associated Molecular Patterns (DAMPs), which can activate NLR family pyrin domain-containing 3 (NLRP3) and assemble with pro-caspase-1 and adaptor protein ASC to form inflammasomes

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At the same time, islet-only grafts failed to achieve effective glycemic control, indicating that TA-PVP encapsulation successfully protected islets from immune reactions and contributed to glucose homeostasis