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At the same time, an increasing body of evidence became available on the emerging network of ACKs and DAMPs/alarmins and their potential role in neuroinflammation and ischemic stroke

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While prior studies mainly concentrated on the direct impact of microbial metabolites on the hosts immune cells, whether these metabolites can modulate the function of tumor cells remained unclear (260)

Several studies indicate that human cells can also actively trigger ROS production at small doses, as part of signaling pathways, regulating cell survival and proliferation, as a defense mechanism against invaders (Bartosz, 2009