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Exemplary conservative amino acids substitution groups are : valine-leucine-isoleucine, phenylalanine-tyrosine, lysine-arginine, alanine-valine, and asparagine-glutamine

Exclusion criteria were death before the 8th day or after the 12th month after birth, cases in which death was expected due to existing illnesses, an unnatural cause of death, and inadequate knowledge of the German language by the parents, so that no declaration of consent could be obtained

Shamanna K, Krishnamurthy M

Another study providing pharmacological evidence of altered MTs regulation and its impact on Zn homeostasis in obesity was conducted by Mota Martins et al