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IBD is frequently complicated by intestinal perforation, stricture formation, and colorectal neoplasia, thereby imposing substantial long-term morbidity, impairing quality of life, and amplifying the global socioeconomic and health-care burden

Therefore, diets should contain the appropriate class of compounds in adequate proportions

2297-C DEVELOPMENT OF A NOVEL IN VITRO MITOCHONDRIAL TOXICITY TEST BASED ON ATP INHIBITION SUBSTRATE ASSAY Hyunwoo Oh 1 , Hyo Young Lee 1 , Eileen Yoon 2 , Huiyul Park 3 , Sang Bong Ahn 4 , Joo Hyun Sohn 2 and Dae Won Jun 2 , (1)Uijeongbu Eulji Medical Center, (2)Hanyang University College of Medicine, (3)Hanyang University, (4)Eulji Medical Center Background: Mitochondrial toxicity has led to the withdrawal of numerous drugs from the market, highlighting the importance of assessing mitochondrial dysfunction during drug development

Samples were analysed by RT-PCR using primers bordering a cluster of three NRF2 consensus sites in the SLC7A11 promoter (forward 53: AGGCTTCTCATGTGGCTGAT