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In the KRAS-driven lung squamous cancer, enforced expression of SOX2 and/or loss of NKX2-1 leads to an increased TANs and promotes lung cancer tumorigenesis

Thus the discovery of cuproptosis reveals that the targets and pathways involved in Cu-dependent cell death are highly correlated with mitochondrial respiration proteins, showing increasing expect for drug discovery

2.6 An integrated framework for UC pathogenesis Overall, the pathogenesis of UC reflects a complex interplay among multiple etiologic factors rather than a single determinant