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Effects of refined xiaoyaosan on depressive-like behaviors in rats with chronic unpredictable mild stress through neurosteroids, their synthesis and metabolic enzymes

And in the eyes, tiny vessels weaken, light itself becoming clouded through retinopathy

All these changes have been linked to the existence of a chronic detrimental low-grade inflammatory state in the adipose tissue (62)

Promising drug categories include: cholesterol-lowering drugs (e.g., aramchol), 104 FXR agonists (e.g., obeticholic acid, 105 tropifexor), 106 PPAR agonists [e.g., elafibranor (PPAR /), 107 saroglitazar (PPAR /), 108 pemafibrate (PPAR) 109 ], Thyroid hormone receptor agonists (e.g., resmetirom), 110 and FGF21 analog (e.g., pegbelfermin)