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ASCs secrete such auto-destructive factors as rheumatoid factor (RF) and ACPA, which are involved in the pathogenesis of RA (68)

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p38 MAPK has been shown to inhibit oncogenic Hras (encode Hras, or Harvey Rat sarcoma virus or transforming protein p21) malignant transformation and ROS- activation of p38 signaling may trigger cell cycle arrest, suppress cell growth and division of cancer cells (Dolado et al