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Given the difficulty of targeting endothelial cells in the dermis, inhibiting downstream pathways activating melanocytes, like EDN-1/EDN receptor signaling [176,177,178,179], could be particularly relevant for treating melasma and solar lentigo as this signaling pathway is upregulated in these conditions [180]

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The amine group of lysine can become mono-, di-, or trimethylated by histone methyltransferases (HMTs) [20], and demethylated by histone demethylases (KDM) [21, 22], altering chromatin structure and thus regulating transcription [22]