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24 These mutations serve as key molecular discriminators between glioma subtypes and are highly prevalent in lower-grade diffuse gliomas (WHO grades IIIII) and secondary GBMs 25 but are largely absent in primary GBMs, which are predominantly IDH wild-type

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2010) that include matrix-assisted laser desorption/ionization time of flight (MALDI-Tof), surface-enhanced laser desorption/ionization time of flight (SELDITof) and electrospray ionization liquid chromatography tandem mass spectrometry (ESI LCMS/MS)