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Moreover, gut microbiota-derived metabolites, including D-amino acids and reactive oxygen species, contribute directly to glomerular and tubular dysfunction by promoting oxidative stress and insulin resistance (Nagase et al., 2022)

Abstract The pharmacological effects of intraperitoneal (i.p.) and intranasal (i.n.) administration of the peptides selank (300 g/kg/day), noopept (1 mg/kg/day), and semax (0.6 mg/kg/day), which are known to possess anxiolytic and nootropic properties, were compared by studying the elevated-plus-maze (EPM) behavior of inbred BALB/c and C57BL/6 mice, and studying their effects on NMDA- and mGluII- receptors in the brain

However, high doses might cause side effects like gastrointestinal issues, allergic reactions, or skin rashes in some individuals

PMID: 34850093 NeuroreportKnockdown circular RNA circGFRA1 inhibits glioma cell proliferation and migration by upregulating microRNA-99a