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Conclusion and perspective Research on lactate metabolism and lactate-derived lactylation, as core drivers of cancer initiation and progression, is gradually changing our traditional perception of lactate as a metabolic waste product. This review systematically examines the basic mechanisms of lactate metabolism, its abnormal manifestations in tumor cells, and the multiple roles of lactate in the TME

Approximately 40% of individuals with FHI do not have an identifiable mutation in any of the genes known to be associated with FHI

Follicular regulatory helper T cells play a rather ambiguous role in regulating the humoral immune response

J Trace Elem Med Biol: Organ Soc Miner Trace Elem (GMS) 28:492494