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The cells were grown until 80% confluence

When extracellular stimuli, such as cytokines, bind to specific cell-surface receptors, they activate the tyrosine kinases Jak (Janus kinase), that phosphorylates STAT proteins, thereby allowing translocation to the nucleus to drive transcription of several chemokines and cytokines

TNX-102 SL at 5.6 mg was demonstrated to be effective for treatment of PTSD, while treatment with 2.8 mg was sub-optimal