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A review of the medical examination data from 25 autistic children found that 53% of these patients had increased pyruvate levels, 76% had elevated blood lactate, in 20% of them the lactate/pyruvate ratio in fibroblasts was increased, and 42% were presented with atypical results of urine organic acid analysis [72]

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These studies in fish were also in accordance with those conducted using mammals, and commercial poultry and pigs that indicated that the antioxidant action of LC may be related to the scavenging of lipid peroxidation products and boosting of redox signalling via the activation of the Nrf2-Keap1 pathway (Reference Gulcin65Reference Surai67)

In support of our work, peripheral alterations in mitochondrial metabolism 39 and myopathy 12,52 have recently been observed in patients with long COVID, but how post-exertional malaise alters skeletal muscle alterations requires further confirmation