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doi:10.1007/s00018-016-2194-1 35

This method, known as the sandwich method, can also help minimize irritation by ensuring the skin is well-hydrated

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[5] [6] Skin conditions Severe cystic acne (e.g., nodulocystic) and rosacea: isotretinoin (13-cis-retinoic acid) PO Mild acne: topical vitamin A Acute promyelocytic leukemia: all-trans retinoic acid (ATRA) Vitamin A should be given to measles patients with vitamin A deficiency to boost their immune system and reduce the risk of complications and mortality, especially in countries where vitamin A deficiency is endemic