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SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells

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It supports the activity of T-cells and natural killer cells, both of which are critical for fighting infections

In liver injury, CHAC1s promotion of GSHdegradation accelerates oxidative stress and liver cell death, while in atherosclerosis, it contributes to plaque instability by promoting apoptosis in lesional macrophages and smooth muscle cells (Xu et al., 2023