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While both studies demonstrated enhanced emotional and physical well-being and a reduction in body weight and BMI, significant alterations in thyroid function tests were observed only in the study by Ihnatowicz et al

In clinical trials, retatrutide has been administered via subcutaneous injection on a once-weekly basis, with doses escalating gradually over several weeks to improve tolerability

Kebabian JW, Petzold GL, Greengard P (1972) Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the dopamine receptor

In addition, the narrow age range of the study subjects that was included as a strength to minimize age-related variation limits the extrapolation of the results to other age groups such as children and adults