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It is commonly studied in relation to copper-peptide signaling, extracellular matrix research models, tissue-response pathways, angiogenesis-related mechanisms, inflammatory signaling environments, epithelial peptide interactions, cell-migration pathways, and actin-binding protein biology

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The downregulation of VGF reduces the formation of dendritic spines, damages synaptic plasticity, and ultimately leads to depressive-like behavior 138

Thiopurines are associated with a high risk of toxicity and careful monitoring is advised[42]