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7, 8-Dihydroxyflavone and baicalin are two flavonoids with similar effects, blocking key inflammatory signaling pathways, including NF-B and JNK, in macrophages, reducing insulin resistance in overweight individuals (208, 209)

On the other hand, evidence indicates that estradiol also plays an important role in differentiating the human brain during early prenatal stages and even after birth (Gillies and McArthur, 2010)