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In one study, CHO-derived reporter cells (AS52) were irradiated with filtered monochromatic light (within the 290600 nm range, 14 W/m 2 , up to 150 kJ/m 2 ), revealing that DNA excision by the repair enzyme Fpgprimarily recognizing 8-oxo-dGpeaked in the blue region between 400 and 450 nm, with a maximum at 420 nm (ref

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The first, ERKO CH , involved disruption of key domains in the receptor protein

Thus, paradoxically, dietary NAC, while increasing resistance against oxidative stress due to accumulation of antioxidant thiols, simultaneously blunts the endogenous cytoprotective gene network, resulting in a shortened lifespan