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This metabolic inflexibility in Insr P1195L/ + mice could be also due to compensatory increase in fat utilization in fat and skeletal muscle during dark phase caused by impaired glucose uptake in these tissues

Potential Side Effects & Safety Measures Semaglutide is generally well-tolerated but may cause: Gastrointestinal symptoms, such as nausea, constipation, diarrhoea Rare headache or fatigue Clinics offer strategies to ease these effects

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