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doi: 10.1016/j.freeradbiomed.2014.07.046

[DOI] [PMC free article] [PubMed] [Google Scholar] 214.Reumann S., Quan S., Aung K., Yang P.F., Manandhar-Shrestha K., Holbrook D., Linka N., Switzenberg R., Wilkerson C.G., Weber A.P.M., et al

Phenotype screening directly targets disease phenotypes (such as viral replication inhibition) to assess drug activity, whereas TBDD first identifies molecular targets associated with the disease (such as key enzymes) before designing compounds to modulate their functions