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Endoscopic remission at Week 52 15* ENTYVIO IV ENTYVIO SC Placebo CI=confidence interval

Due to the increasing use of sunscreens and less outdoor activities, we are not absorbing the necessary amounts of sun needed to adequately keep our Vitamin D3 stores

Absolute contraindications: Known allergy to either peptide or its components Active cancer (insufficient safety data) Pregnancy or breastfeeding (insufficient safety data) Severe immunocompromise (theoretical concern) Relative contraindications (require careful consideration): History of cancer (consult a medical advisor) Major cardiac disease (monitor closely) Severe liver or kidney disease (may affect clearance) Active infections (wait until resolved) Bleeding disorders (monitor injection sites carefully) Special populations: Elderly subjects: usually well tolerated, no dose adjustment needed Subjects with multiple conditions: enhanced monitoring recommended Those on multiple medications: review for possible interactions Drug Interactions The peptides have minimal documented drug interactions

GHK-Cu remains one of the more effective non-hormonal options for this group