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8.3 Microenvironment-based strategies Addressing the issue of oxidative stress in IVDD, some studies have attempted to use various metal or non-metal nanomaterials to simulate endogenous ROS-degrading enzymes for ROS clearance

PMCID: PMC9497579 Loeys BL, Schwarze U, Holm T, Callewaert BL, Thomas GH, Pannu H, De Backer JF, Oswald GL, Symoens S, Manouvrier S, Roberts AE, Faravelli F, Greco MA, Pyeritz RE, Milewicz DM, Coucke PJ, Cameron DE, Braverman AC, Byers PH, De Paepe AM, Dietz HC

The frequency of injections depends on the individual's medical condition and the prescription provided by the healthcare provider

Additionally, certain synthetic thermosensitive polymers can be utilized to fabricate NIR-responsive delivery platforms in conjunction with NIR-responsive particles [377]