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Your provider evaluates which route (or combination of routes) fits your physiology instead of defaulting to a single recommendation

Fatigue is listed as a common adverse reaction in FDA prescribing information, occurring in 5% or more of patients taking Wegovy (semaglutide 2.4 mg) and Zepbound (tirzepatide), with higher frequency than placebo in clinical trials

1% yeast extract, 2% peptone, and 2% glucose)

Common experiences after the first injection include: Mild soreness or redness at the injection site (usually resolves within 12 days) Slight improvement in energy levels or mood No immediate noticeable change (particularly common if deficiency is severe) Rarely, mild side effects such as headache or dizziness Some patients report their urine becoming brighter or more intensely coloured following injection, which occurs because excess B12 is excreted renally