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doi: 10.1016/j.chembiol.2020.10.010, 78 Mahoney-SanchezL.BouchaouiH.BoussaadI.JonneauxA.TimmermanK.BerdeauxO.et al

PMID: 40605992 J Med Chem Enzyme-Triggered Charge and Conformation Switching for Tumor-Selective Peptide-Drug Conjugates

Several situations warrant pausing at a dose level for additional weeks before escalating: Persistent nausea: If nausea lasts beyond 2 weeks at any dose level, stay at that dose for an additional 2 to 4 weeks