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Interestingly, PD is also associated with iron overload and lipid peroxidation, which are highly consistent with ferroptosis, a form of regulated cell death that is initiated by iron-dependent phospholipid peroxidation (4)

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In conclusion, compared to normal cells, tumor cells exhibit a significantly higher ratio of de novo synthesized fatty acids, and this metabolic shift is positively correlated with tumor malignancy (62)

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