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GHK has been shown to enhance extracellular matrix (ECM) activity in both dermal and pulmonary fibroblasts

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The 15-residue linear sequence contains no cysteine residues, no disulfide constraints, and no unnatural amino acids, yet it maintains stability under conditions that would degrade nearly any other peptide of comparable size

Further, the extraordinary affinity of HGF for Dihexa (Kd=2.2 x 10 "13 M) suggests that normally non- biologically active levels of HGF become physiologically relevant in the presence of a high affinity mimetic