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These include checkpoint blockade plus anti-angiogenic therapy [176], macrophage reprogramming agents such as CD47 inhibitors [177, 178], TME-targeted cytokine inhibitors such as anti-IL6 or anti-TGF- antibodies [179, 180], and oncolytic virotherapy [181]

That preservative is what makes it the default choice for multi-dose research vials a solution reconstituted with bacteriostatic water can typically be accessed multiple times over its usable window without the same contamination risk that a preservative-free solvent would carry