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In addition, tumor cells secrete vascular endothelial growth factor (VEGF) to recruit TAMs, which become a major source of angiogenic factors via NF-B and STAT3 activation (92)

At the same time, it has been shown that melatonin supplementation can positively affect fertility and improve the effectiveness of assisted reproductive protocols (25), which may be related to its influence on the increase of melatonin concentration in the follicular fluid (25, 98)

Phase I/II Trial of AEG35156 X-Linked Inhibitor of Apoptosis Protein Antisense Oligonucleotide Combined With Idarubicin and Cytarabine in Patients With Relapsed or Primary Refractory Acute Myeloid Leukemia