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Additionally, thiamines effects on prostaglandins, reactive oxygen species, cyclooxygenase-2, matrix metalloproteinases, and nitric oxide synthase have been linked to cancer (89)

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PT, a methoxylated analog of resveratrol, exhibits pleiotropic pharmacological activities including anti-cancer, neuroprotective, anti-obesity, anti-diabetic and anxiolytic activities ( Compared with retinoids, PT displays equivalent procollagen I restoration yet superior suppression of mitochondrial ROS without provoking erythema, desquamation, or photosensitivity ( Malfunctioning mitochondria can lead to a wide range of cellular problems, including increased oxidative stress and impaired energy metabolism ( Mitochondrial dynamics, biogenesis, and mitophagy are crucial processes that coordinate to maintain mitochondrial homeostasis and restore damaged mitochondrial function ( Statements Data availability statement The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding authors