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However, in PD pathogenesis, oligomerisation of S downregulates Sirt3 (Park et al., 2020), resulting in decreased phosphorylation of AMPK and increased phosphorylation of Drp1, impairing mitochondrial respiration, and leading to apoptosis

It is primarily made up of three amino acids: glutamine, glycine and cysteine

In addition, when GSH is depleted, monocyte-derived macrophages significantly increase their production of reactive oxygen species (ROS), further amplifying oxidative damage within the CNS (Canton et al., 2021)

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