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doi: 10.3390/nu16101468 126 SongJLuoXXiongLLiSChenYLiuWet al

Cardiometabolic diseases (e.g., heart failure, T2D, hypertension) accelerate frailty, and conversely, frailty predicts worse cardiovascular and cognitive outcomes [38]

This study is notable because it used human cells (not mouse cells), providing evidence that FOXO4-DRI's mechanism functions in human biology at least in a cell culture context