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7.3.6 Clinical translation Successful translation of ferroptosis-targeted therapies requires methodical progression through several key stages: validation of candidate biomarkers in well-characterized human cohorts, optimization of inhalation formulations for consistent pulmonary deposition, and demonstration of safety and efficacy through rigorously designed clinical trials

Compounds that bind iron, such as ciclopirox olamine (CPX), DFO, and deferiprone (DFP), inhibit ferroptosis by chelating iron ions and subsequently reducing ROS production (206, 207)

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Our metabolomic study in human umbilical-vein endothelial cells (HUVECs) found that GTE could exert its anti-angiogenic properties through suppressing synthesis of cellular building blocks and oxidative-phosphorylation metabolites, while promoting the synthesis of membrane lipids and growth factors (73)