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Study 2: Selective Small-Molecule Inhibitors (including 5-Amino-1MQ) A selective, membrane-permeable NNMT inhibitor series decreased intracellular 1-MNA, increased NAD and SAM, suppressed adipocyte lipogenesis, and reversed high-fat-diet obesity in mice

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For instance, AMPD is a purine metabolic enzyme that converts AMP to IMP (see section Adenosine Production within the BM Niche)

RM-493, a melanocortin-4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals