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Table: categorization by benefit and status Tissue repair/anti-inflammatory: BPC-157 preclinical strong, clinical absent Immune modulation: Thymosin Alpha-1 early clinical evidence in immune-related reproductive failure Angiogenesis/repair: GHK-Cu preclinical angiogenic data, small translational interest Hormonal regulation: Kisspeptin clinical trials underway, biomarker use proposed Antimicrobial/microbiome: LL-37 preclinical and early safety work

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(2020a) demonstrated the in vitro effect of ethyl acetate extract (25, 50, and 100 g/ml) of Z

The differentially expressed genes were filtered using the condition Fold change 2 or 2 and the genes that fulfilled that condition were listed (Supplementary Data 13)