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On the other hand, nickel and cadmium seem to decrease the reduction rate (Pal et al

J Pharmacol Exp Ther 305 , 974980, (2003)

Selenium, essentially needed for the biosynthesis of selenoproteins, e.g.GPx, that are involved in antioxidative defense systems and lipid metabolism

The review discusses how physicochemical propertiessuch as size, shape, and surface chemistryinfluence cytotoxicity through mechanisms like oxidative stress, mitochondrial damage, and DNA disruption