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Homocysteine promotes the proliferation and IFN- expression of mouse splenic T cells ( BHMT1 in CD4+ T cells, reduced serum homocysteine level, increased the number of regulatory T cells, and prevented disease progression ( in vitro calcitriol treatment increased global DNA methylation in splenic CD4+ T cells, suggesting that reduction in homocysteine may be critical in stabilizing the phenotype of regulatory T cells ( Tumor methionine metabolism drives T cell exhaustion T cell exhaustion is a common state induced by chronic antigen exposure and in tumor-infiltrating lymphocytes