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Aging Cell 13 , 273282 (2014)

Despite promising preclinical results with inhibitors (e.g., ferrostatin-1) and gene therapies targeting GPX4/ACSL4, clinical translation faces critical barriers: the poorly defined temporal dynamics of ferroptosis post-stroke hinders therapeutic window optimization, and its interplay with necroptosis/pyroptosis requires clarification to guide combination therapies

Using a proper technique, rotating injection sites, and applying a warm compress to the area can help reduce discomfort

The primary risk of taking them together is stacked sedation, which can impair coordination and alertness